Protein C Variant Database
PROC Variant
Protein C deficiency (PCD) is a condition caused by mutations in the PROC gene, which encodes coagulation PROC, a key component in anticoagulation. This database contains 507 unique variants of the PROC gene.
Data Source
We provide a comprehensive resource on genetic variants in human anticoagulation factors, with a specific focus on the PROC gene, serving the needs of clinicians and biochemists worldwide. This database is regularly updated and currently includes data from 119 references (last updated November 2023). Data from 4,003 individual cases of PCD.
Search
Simple Nucleotide
Simple Amino Acid
What can you do in this database?
Basic Information on PROC
Access detailed information on the PROC gene and its role in coagulation, including standardized descriptions of PROC variations (submit page). This section offers a clear and precise understanding of the genetic basis of PCD.
cDNA and HGVS Variations Query
Utilize the standard cDNA mutation and HGVS protein queries to explore specific variations. This allows users to view genetic variations and their corresponding protein changes in an organized, searchable format.
Advanced Search
Conduct a more refined search based on specific parameters relevant to your research or clinical interests. The advanced search function provides flexibility, enabling users to filter results by mutation type, clinical characteristics, and other genetic or patient-related data.
Citing us
Zhang, S., Dong, S., Hou, Z., Liu, S., Lyu, C., Zhou, H., Ai, L. J., Guo, Y., Dong, Y., Zhao, M., Li, T., Jiang, B., Zhai, T., Pan, J., Wang, W., Hao, D., & Shen, G. (2025).
Novel insights into inherited protein C deficiency from an interactive PROC variant database.
Journal of thrombosis and haemostasis : JTH, S1538-7836(25)00493-3.