Mutations Mapped on to the subdomains of PROC

  • All amino acids that are colored in black-bold font have associated mutations (point) within the database.
  • More information on each amino acid mutation and its effects on the structure can be gained by clicking it.
  • This display is automatically generated and represents all the amino acid mutations at that residue within PROC.

PROC: signal peptide--propeptide--Gla--EGF1--EGF2--linker--activation peptide--serine protease domain

MWQLTSLLLF    VATWGISGTP    APLDSVFSSS    ERAHQVLRIR    KRANSFLEEL      50

RHSSLERECI    EEICDFEEAK    EIFQNVDDTL    AFWSKHVDGD    QCLVLPLEHP      100

CASLCCGHGT    CIDGIGSFSC    DCRSGWEGRF    CQREVSFLNC    SLDNGGCTHY      150

CLEEVGWRRC    SCAPGYKLGD    DLLQCHPAVK    FPCGRPWKRM    EKKRSHLKRD      200

TEDQEDQVDP    RLIDGKMTRR    GDSPWQVVLL    DSKKKLACGA    VLIHPSWVLT      250

AAHCMDESKK    LLVRLGEYDL    RRWEKWELDL    DIKEVFVHPN    YSKSTTDNDI      300

ALLHLAQPAT    LSQTIVPICL    PDSGLAEREL    NQAGQETLVT    GWGYHSSREK      350

EAKRNRTFVL    NFIKIPVVPH    NECSEVMSNM    VSENMLCAGI    LGDRQDACEG      400

DSGGPMVASF    HGTWFLVGLV    SWGEGCGLLH    NYGVYTKVSR    YLDWIHGHIR      450

DKEAPQKSWA    P*



Alpha missense prediction