| Mutation type:Point | Mutation effect:Missense | Nucleotide number:94 | |||
| Genome location:Exon3 | Subdomain:Propeptide | ||||
| Alpha missense prediction value:0.1636 | Alpha missense prediction class:benign | ||||
| No. of patients reported: 21 | |||||
| Patient information: Monoallelic variation (21); Biallelic variation (0) | |||||
| Patient | Sex | Age | Genotype | PC: amidolytic act (%) | PC: clotting act (%) | PC: Ag (%) | PCD type | Clinical presentation (age) | First onset age | Country | Comments | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | NA | hetero | NA | 40 | 55 | I | Other VTE (24) | 24 | Italy | thrombosis (Other VTE); anticoagulant therapy | PMID: 8829639 |
| 2 | M | NA | hetero | NA | 50 | 60 | I | Other VTE (42) | 42 | Italy | thrombosis (Other VTE); anticoagulant therapy | PMID: 8829639 |
| 3 | M | NA | hetero | NA | NA | 65 | I | asymptomatic | NA | Italy | NA | PMID: 8829639 |
| 4 | F | NA | hetero | NA | NA | 60 | I | asymptomatic | NA | Italy | NA | PMID: 8829639 |
| 5 | F | NA | hetero | NA | 49 | 50 | I | NA | NA | Italy | NA | PMID: 8829639 |
| 6 | NA | NA | hetero | 52.6 | 52 | 50.2 | I | Other VTE | NA | France | NA | PMID: 32717757 |
| 7 | NA | NA | hetero | 52.6 | 52 | 50.2 | I | Other VTE | NA | France | NA | PMID: 32717757 |
| 8 | NA | NA | hetero | 52.6 | 52 | 50.2 | I | asymptomatic | NA | France | NA | PMID: 32717757 |
| 9 | NA | NA | hetero | 52.6 | 52 | 50.2 | I | asymptomatic | NA | France | NA | PMID: 32717757 |
| 10 | NA | NA | hetero | 52.6 | 52 | 50.2 | I | asymptomatic | NA | France | NA | PMID: 32717757 |
| 11 | F | 86 | hetero | NA | 42 | 33 | I | miscarriage (38), DVT (45) | 38 | Italy | NA | PMID: 22168450 |
| 12 | F | 65 | hetero | NA | 18 | 21 | I | DVT (50, 61) | 50 | Italy | FVL | PMID: 22168450 |
| 13 | M | 63 | hetero | NA | 53 | 45 | I | DVT, TIA (53, 61) | 53 | Italy | FVL | PMID: 22168450 |
| 14 | F | 59 | hetero | NA | 59 | 64 | I | MI (54); TIA (57) | 54 | Italy | NA | PMID: 22168450 |
| 15 | F | 54 | hetero | NA | 60 | 59 | I | DVT (27, 53) | 27 | Italy | FVL | PMID: 22168450 |
| 16 | F | 22 | hetero | NA | 57 | 45 | I | DVT (21) | 21 | Italy | FVL. oral estrogen therapy | PMID: 22168450 |
| 17 | F | 34 | hetero | NA | 51 | 38 | I | asymptomatic | 34 | Italy | NA | PMID: 22168450 |
| 18 | F | 33 | hetero | NA | 46 | 38 | I | asymptomatic | 33 | Italy | NA | PMID: 22168450 |
| 19 | M | 40 | hetero | NA | 56 | 45 | I | asymptomatic | 40 | Italy | NA | PMID: 22168450 |
| 20 | M | 18 | hetero | NA | 25 | 45 | I | asymptomatic | 18 | Italy | NA | PMID: 22168450 |
| 21 | F | 12 | hetero | NA | 55 | 43 | I | asymptomatic | 12 | Italy | NA | PMID: 22168450 |
| Mutation type:Point; Point | Mutation effect:Missense; Missense | Nucleotide number:94; 94 | |||
| Genome location:Exon3; Exon3 | Subdomain:Propeptide; Propeptide | ||||
| Alpha missense prediction value:0.1636; 0.1636 | Alpha missense prediction class:benign; benign | ||||
| No. of patients reported: 3 | |||||
| Patient information: Monoallelic variation (0); Biallelic variation (3) | |||||
| Patient | Sex | Age | Genotype | PC: amidolytic act (%) | PC: clotting act (%) | PC: Ag (%) | PCD type | Clinical presentation (age) | First onset age | Country | Comments | Reference |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NA | NA | homo | NA | 12 | 16 | I | Other VTE (1M) | 1M | Italy | thrombosis (Other VTE) | PMID: 8829639 |
| 2 | M | 61 | homo | NA | 5 | 5.35 | I | DVT and PE (12, 15) | 12 | Italy | the father died of stroke (46). FVL | PMID: 22168450 |
| 3 | M | 51 | homo | NA | 9 | 5.35 | I | DVT (14, 16) | 14 | Italy | FVL | PMID: 22168450 |